Methylenetetrahydrofolate reductase and angiotensin converting enzyme gene polymorphisms in two genetically and diagnostically distinct cohort of Alzheimer patients.
Identifieur interne : 001E10 ( Main/Exploration ); précédent : 001E09; suivant : 001E11Methylenetetrahydrofolate reductase and angiotensin converting enzyme gene polymorphisms in two genetically and diagnostically distinct cohort of Alzheimer patients.
Auteurs : Davide Seripa [Italie] ; Gloria Dal Forno ; Maria G. Matera ; Carolina Gravina ; Maurizio Margaglione ; Mark T. Palermo ; David R. Wekstein ; Piero Antuono ; Daron G. Davis ; Antonio Daniele ; Carlo Masullo ; Alessandra Bizzarro ; Massimo Gennarelli ; Vito M. FazioSource :
- Neurobiology of aging [ 0197-4580 ] ; 2003.
Descripteurs français
- Wicri :
- geographic : Italie, États-Unis.
English descriptors
- KwdEn :
- Age of Onset, Aged, Aged, 80 and over, Aging (genetics), Alzheimer Disease (classification), Alzheimer Disease (diagnosis), Alzheimer Disease (enzymology), Alzheimer Disease (ethnology), Alzheimer Disease (genetics), Case-Control Studies, Chi-Square Distribution, Cohort Studies, European Continental Ancestry Group (genetics), Female, Genetic Linkage, Genetic Predisposition to Disease, Humans, Italy (epidemiology), Male, Methylenetetrahydrofolate Reductase (NADPH2) (genetics), Middle Aged, Peptidyl-Dipeptidase A (genetics), Polymorphism, Genetic, Reference Values, Risk Factors, United States (epidemiology).
- MESH :
- chemical , genetics : Methylenetetrahydrofolate Reductase (NADPH2), Peptidyl-Dipeptidase A.
- geographic , epidemiology : Italy, United States.
- classification : Alzheimer Disease.
- diagnosis : Alzheimer Disease.
- enzymology : Alzheimer Disease.
- ethnology : Alzheimer Disease.
- genetics : Aging, Alzheimer Disease, European Continental Ancestry Group.
- Age of Onset, Aged, Aged, 80 and over, Case-Control Studies, Chi-Square Distribution, Cohort Studies, Female, Genetic Linkage, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Polymorphism, Genetic, Reference Values, Risk Factors.
Abstract
The role of methylenetetrahydrofolate reductase (MTHFR) and angiotensin converting enzyme (ACE) gene polymorphisms as risk factors for the occurrence of Alzheimer's disease (AD) is still controversial. In this study, we investigated the common MTHFR C677-->T and ACE insertion/deletion (I/D) gene polymorphisms as risk factors for AD in two genetically and diagnostically distinct cohort of Alzheimer's patients. We analyzed a neuropathologically confirmed American cohort of 124 AD patients and 97 elderly controls, and a clinically diagnosed Italian cohort of 126 probable AD cases, 106 elderly controls, and a community-based sample of 1232 subjects aged under 65 years. No difference was found in polymorphism distribution between cases and controls in both study cohorts. We also tested a possible association between the polymorphisms investigated. No interaction was found between the MTHFR and ACE alleles. Moreover, no association was found for the ACE and MTHFR polymorphisms with age at onset, disease duration and MMSE score at observation. Thus, in our study, MTHFR C677-->T and ACE I/D polymorphisms do not appear to confer an added risk for AD.
PubMed: 12928053
Affiliations:
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Matera</name></author><author><name sortKey="Gravina, Carolina" sort="Gravina, Carolina" uniqKey="Gravina C" first="Carolina" last="Gravina">Carolina Gravina</name></author><author><name sortKey="Margaglione, Maurizio" sort="Margaglione, Maurizio" uniqKey="Margaglione M" first="Maurizio" last="Margaglione">Maurizio Margaglione</name></author><author><name sortKey="Palermo, Mark T" sort="Palermo, Mark T" uniqKey="Palermo M" first="Mark T" last="Palermo">Mark T. Palermo</name></author><author><name sortKey="Wekstein, David R" sort="Wekstein, David R" uniqKey="Wekstein D" first="David R" last="Wekstein">David R. Wekstein</name></author><author><name sortKey="Antuono, Piero" sort="Antuono, Piero" uniqKey="Antuono P" first="Piero" last="Antuono">Piero Antuono</name></author><author><name sortKey="Davis, Daron G" sort="Davis, Daron G" uniqKey="Davis D" first="Daron G" last="Davis">Daron G. 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Matera</name></author><author><name sortKey="Gravina, Carolina" sort="Gravina, Carolina" uniqKey="Gravina C" first="Carolina" last="Gravina">Carolina Gravina</name></author><author><name sortKey="Margaglione, Maurizio" sort="Margaglione, Maurizio" uniqKey="Margaglione M" first="Maurizio" last="Margaglione">Maurizio Margaglione</name></author><author><name sortKey="Palermo, Mark T" sort="Palermo, Mark T" uniqKey="Palermo M" first="Mark T" last="Palermo">Mark T. Palermo</name></author><author><name sortKey="Wekstein, David R" sort="Wekstein, David R" uniqKey="Wekstein D" first="David R" last="Wekstein">David R. Wekstein</name></author><author><name sortKey="Antuono, Piero" sort="Antuono, Piero" uniqKey="Antuono P" first="Piero" last="Antuono">Piero Antuono</name></author><author><name sortKey="Davis, Daron G" sort="Davis, Daron G" uniqKey="Davis D" first="Daron G" last="Davis">Daron G. Davis</name></author><author><name sortKey="Daniele, Antonio" sort="Daniele, Antonio" uniqKey="Daniele A" first="Antonio" last="Daniele">Antonio Daniele</name></author><author><name sortKey="Masullo, Carlo" sort="Masullo, Carlo" uniqKey="Masullo C" first="Carlo" last="Masullo">Carlo Masullo</name></author><author><name sortKey="Bizzarro, Alessandra" sort="Bizzarro, Alessandra" uniqKey="Bizzarro A" first="Alessandra" last="Bizzarro">Alessandra Bizzarro</name></author><author><name sortKey="Gennarelli, Massimo" sort="Gennarelli, Massimo" uniqKey="Gennarelli M" first="Massimo" last="Gennarelli">Massimo Gennarelli</name></author><author><name sortKey="Fazio, Vito M" sort="Fazio, Vito M" uniqKey="Fazio V" first="Vito M" last="Fazio">Vito M. Fazio</name></author></analytic><series><title level="j">Neurobiology of aging</title><idno type="ISSN">0197-4580</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age of Onset</term><term>Aged</term><term>Aged, 80 and over</term><term>Aging (genetics)</term><term>Alzheimer Disease (classification)</term><term>Alzheimer Disease (diagnosis)</term><term>Alzheimer Disease (enzymology)</term><term>Alzheimer Disease (ethnology)</term><term>Alzheimer Disease (genetics)</term><term>Case-Control Studies</term><term>Chi-Square Distribution</term><term>Cohort Studies</term><term>European Continental Ancestry Group (genetics)</term><term>Female</term><term>Genetic Linkage</term><term>Genetic Predisposition to Disease</term><term>Humans</term><term>Italy (epidemiology)</term><term>Male</term><term>Methylenetetrahydrofolate Reductase (NADPH2) (genetics)</term><term>Middle Aged</term><term>Peptidyl-Dipeptidase A (genetics)</term><term>Polymorphism, Genetic</term><term>Reference Values</term><term>Risk Factors</term><term>United States (epidemiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Methylenetetrahydrofolate Reductase (NADPH2)</term><term>Peptidyl-Dipeptidase A</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Italy</term><term>United States</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Alzheimer Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Alzheimer Disease</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Alzheimer Disease</term></keywords><keywords scheme="MESH" qualifier="ethnology" xml:lang="en"><term>Alzheimer Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Aging</term><term>Alzheimer Disease</term><term>European Continental Ancestry Group</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age of Onset</term><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Chi-Square Distribution</term><term>Cohort Studies</term><term>Female</term><term>Genetic Linkage</term><term>Genetic Predisposition to Disease</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Genetic</term><term>Reference Values</term><term>Risk Factors</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Italie</term><term>États-Unis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The role of methylenetetrahydrofolate reductase (MTHFR) and angiotensin converting enzyme (ACE) gene polymorphisms as risk factors for the occurrence of Alzheimer's disease (AD) is still controversial. In this study, we investigated the common MTHFR C677-->T and ACE insertion/deletion (I/D) gene polymorphisms as risk factors for AD in two genetically and diagnostically distinct cohort of Alzheimer's patients. We analyzed a neuropathologically confirmed American cohort of 124 AD patients and 97 elderly controls, and a clinically diagnosed Italian cohort of 126 probable AD cases, 106 elderly controls, and a community-based sample of 1232 subjects aged under 65 years. No difference was found in polymorphism distribution between cases and controls in both study cohorts. We also tested a possible association between the polymorphisms investigated. No interaction was found between the MTHFR and ACE alleles. Moreover, no association was found for the ACE and MTHFR polymorphisms with age at onset, disease duration and MMSE score at observation. Thus, in our study, MTHFR C677-->T and ACE I/D polymorphisms do not appear to confer an added risk for AD.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="Antuono, Piero" sort="Antuono, Piero" uniqKey="Antuono P" first="Piero" last="Antuono">Piero Antuono</name><name sortKey="Bizzarro, Alessandra" sort="Bizzarro, Alessandra" uniqKey="Bizzarro A" first="Alessandra" last="Bizzarro">Alessandra Bizzarro</name><name sortKey="Daniele, Antonio" sort="Daniele, Antonio" uniqKey="Daniele A" first="Antonio" last="Daniele">Antonio Daniele</name><name sortKey="Davis, Daron G" sort="Davis, Daron G" uniqKey="Davis D" first="Daron G" last="Davis">Daron G. Davis</name><name sortKey="Fazio, Vito M" sort="Fazio, Vito M" uniqKey="Fazio V" first="Vito M" last="Fazio">Vito M. Fazio</name><name sortKey="Forno, Gloria Dal" sort="Forno, Gloria Dal" uniqKey="Forno G" first="Gloria Dal" last="Forno">Gloria Dal Forno</name><name sortKey="Gennarelli, Massimo" sort="Gennarelli, Massimo" uniqKey="Gennarelli M" first="Massimo" last="Gennarelli">Massimo Gennarelli</name><name sortKey="Gravina, Carolina" sort="Gravina, Carolina" uniqKey="Gravina C" first="Carolina" last="Gravina">Carolina Gravina</name><name sortKey="Margaglione, Maurizio" sort="Margaglione, Maurizio" uniqKey="Margaglione M" first="Maurizio" last="Margaglione">Maurizio Margaglione</name><name sortKey="Masullo, Carlo" sort="Masullo, Carlo" uniqKey="Masullo C" first="Carlo" last="Masullo">Carlo Masullo</name><name sortKey="Matera, Maria G" sort="Matera, Maria G" uniqKey="Matera M" first="Maria G" last="Matera">Maria G. Matera</name><name sortKey="Palermo, Mark T" sort="Palermo, Mark T" uniqKey="Palermo M" first="Mark T" last="Palermo">Mark T. Palermo</name><name sortKey="Wekstein, David R" sort="Wekstein, David R" uniqKey="Wekstein D" first="David R" last="Wekstein">David R. Wekstein</name></noCountry><country name="Italie"><noRegion><name sortKey="Seripa, Davide" sort="Seripa, Davide" uniqKey="Seripa D" first="Davide" last="Seripa">Davide Seripa</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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